Today’s cyclodextrin is about one of favourite novel DDS: microneedles!
Hydrogel-forming microneedle array patches (HFMAPs) are microneedles that create microconduits upon insertion and swelling in the skin, potentially allowing prolonged drug delivery without generating sharps waste.
To enhance the aqueous solubility and successfully deliver risperidone hydroxypropyl-beta-cyclodextrin (HP-β-CD) and hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) were utilized and their performance was tested using phase solubility studies.
For a 1-day application, HFMAPs showed greater systemic exposure to RIS compared to intramuscular control and exposure was extended to 5 days.
In conclusion, HFMAPs could serve as an alternative for delivering RIS in a sustained manner, potentially improving the treatment of schizophrenia.
Risperidone-cyclodextrin complex reservoir combined with hydrogel-forming microneedle array patches for enhanced transdermal delivery – ScienceDirect
Great work from Queen’s University Belfast and Ryan Donnelly – Lalitkumar Vora, PhD teams.
