After reporting on intracellular protein delivery yesterday, today we share the latest news on RNA delivery to prostate cancer cells using cyclodextrin nanoparticles.
Universidad de Castilla-La Mancha, Instituto de Salud Carlos III, Universidad de Sevilla (Jose Manuel Garcia Fernandez, Valentin Ceña et al)
Now, this is something we have never seen before. Delivering oligonucleotides into cells using cyclodextrin-based nanoparticles has been studied a lot, yet in the paper from Chongqing University, intranucleus delivery of proteins is shown. This will certainly open up new drug delivery possibilities for the future and trigger novel applications.
Read the full article on ScienceDirect
Have you ever tried using cyclodextrin to prevent protein folding and to stabilize them with such safe excipients instead surface active agents? From the patent of Tamas Sohajda, our board member, you can learn more about this potential.
We have known for a long time (at least since our CSO Milo‘s paper “Back to the Future”: A New Look at Hydroxypropyl Beta-Cyclodextrins that the degree of substitution (DS) plays a critical role in cyclodextrin complexation. Now Qiang Fu’s team from Shenyang Pharmaceutical University shares further proof of this by comparing HPBCDs from different sources.
As pharmacopeias currently allow a very wide range of acceptable DS and different types of HPBCDs are available on the market (just compare Kleptose HP and Kleptose HPB from Roquette as an example), this is something certainly to investigate when developing new products.
Articles
https://www.sciencedirect.com/science/article/abs/pii/S0167732222016440?via%3Dihub
https://jpharmsci.org/article/S0022-3549(16)41410-3/fulltext
Great reivew on glycoconjugates, their synthesis and pharmaceutical applications from Scripps Research (Sachin S. Shivatare, PhD, Vidya Shivatare and Chi-Huey Wong)
The cyclodextrin-supported atherosclerosis treatment field is getting crowded. Here is a unique approach using polyethylene glycol succinate (TPGS)-CD, which was adsorbed on rHDL, then modified with Apo-Ai, and coated with hyaluronan to obtain HT-rHDL. Piece of cake!
China Pharmaceutical University
Full article on ScienceDirect
https://doi.org/10.1016/j.carbpol.2022.119632
