What a great day when we can celebrate Carolyn Bertozzi, a pioneer in glycochemistry, and the fathers of click reaction Barry Sharpless and Morten Meldal, whose innovation we use day-by-day in our humble research.
Thank you for your groundbreaking work that enables many and more new discoveries!
Automated solution-phase multiplicative synthesis of complex glycans enabled by preactivation-based, multi-component, one-pot glycosylation and continuous multiplying amplification published by Peking University. Wonderful!
Bathing in carbs: Lai-Xi Wang and his group from the University of Maryland reported the synthesis of cyclodextrin-based multivalent glycan ligands for human galectin-3. The GalNAc (Tn antigen) containing heptavalent ligand showed the highest affinity for human Gal-3 among the synthetic ligands tested, with an EC50 of 1.4 μM in binding to human Gal-3.
Great read on pore-forming lectin SaroL-1 punching holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3 presented by a well-known team led by Anne Imberty (Grenoble University), Winfried Römer (Université de Fribourg – Universität Freiburg) and Frederique Lisacek (University of Geneva)
Fascinating!
Great paper on the relations of Gal-3 levels and Aβ deposits and tau aggregates in #brain tissue in #alzheimersdisease published by a great collaboration of the University of Seville, ENS-PSL, EHESS, Université Paris Cité, Lund University, and the University of Gothenburg.
#neurodegenerativediseases #alzheimers #brainhealth #carbohydrates #glycotime
Great paper from The University of Kansas by Mark P. Farrell and their team on lectin drug conjugates targeting N-glycans.
Read more: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200266
