Peter Seeberger, Felix Loeffler et al. from Max Planck Institute of Colloids and Interfaces published a #chemical vapor glycosylation strategy (VaporSPOT) that enables the simultaneous #synthesis of oligosaccharides on a cellulose #membrane.
Amazing study!
Full article: https://pubs.acs.org/doi/10.1021/jacs.2c07285
The history of ribitol phosphate discovery and the therapeutic strategies currently proposed for musculardystrophy by Motoi Kanagawa from Ehime University
Full article: https://glycoforum.gr.jp/article/25A14.html
Olivier Renaudet, David Goyard, Ángela Martín-Serrano Ortiz and Didier Boturynlick from Université Grenoble Alpes presents click chemistry to decorate synthetic multivalent scaffolds with glycans to mimic the cell surface glycocalyx and to develop applications in glycosciences.
Great reivew on glycoconjugates, their synthesis and pharmaceutical applications from Scripps Research (Sachin S. Shivatare, PhD, Vidya Shivatare and Chi-Huey Wong)
We are always thrilled to see companies adjancing drugs in the field of glycochemistry, just as Palleon Pharmaceuticals. who recently announced patenting engineered human sialidase enzymes that restore antitumor immunity by degrading immunosuppressive sialoglycans on tumors and across immune cell types
Covalent linkages are engineered between proteins and carbohydrates under biocompatible conditions. Genetically encoding the chemical crosslinking of proteins to carbohydrates offers a solution to address the low affinity and weak strength of protein–sugar interactions.
The University of California, San Francisco – Shanshan Li, Nanxi Wang, Bingchen Yu Wei Sun Lei Wang present pure beauty!
Read the full article on nature.com
Jellyfish is considered a new potential resource in the food, pharmaceutical, and biomedical industries. In this study presented by Università di Pisa (Chiara Migone Noemi Scacciati Brunella Grassiri Alessandra Braca Dario Puppi Anna Maria Piras et al), skin polysaccharides with glycosaminoglycan features were extracted, and their use as promoters of wound-healing was evaluated
I.
A significant advantage of using CDs is that they can contribute to the fast onset, the rapid action of different APIs. This is well highlighted in the patent of Fontana Bio and Catalent Pharma Solutions (Anthony Lando and Leon Grother) describing rapidly disintegrating tablets.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2022216769
II.
Evaluation of alpha-CD as intestinal tract function improving agent: an immunopotentiating agent, an antimicrobial agent, a hydrogen generator and/or an antioxidant, each comprising CD together with one or more selected from among a butyric acid bacterium, butyric acid, and acetic acid as active ingredients
Nice patent from Cyclochem (Keiji Terao) and Ace Bio Co.
III.
Polyrotaxanes by Toyoda Gosei Americas / ASM and Denka Company Limited / Tokyo Medical and Dental University. The first one is used to make dielectric sheets made of rubber for sensors and actuators; the other promotes osteolysis and/or lipolysis of mesenchymal stem cells (osteoblast or fat differentiation).
These compounds are fascinating and could be so widely used.
IV.
Getting in a weekend mood? Old but gold: CD (polyrotaxane) covered golfball by Sumitomo Rubber AKO! Go out, play, and enjoy!
#golf #polymer #polymerscience #advancedmaterials
https://patentscope.wipo.int/search/en/detail.jsf?docId=US376038326
V.
It is a little adventure to the nanoworld of Zhengzhou University, which build multi-loaded nanovesicles to encapsulate both hydrophilic and hydrophobic drugs and use them to decrease the formation of foam cells and regulate inflammation.
#nanoparticle #atherosclerosis #drugdelivery
https://www.sciencedirect.com/science/article/abs/pii/S0014305722006000?via%3Dihub
VI.
Smoking will not get you healthy, no matter what you put in your cig. But with CDs, at least you can mask the smell a bit, as this patent from KT&G suggests.
#tobacco #smoking #odormasking
https://patentscope.wipo.int/search/en/detail.jsf?docId=US375618843
Hyaluronic acid-related oligosaccharides were evaluated as potential antiangiogenic agents by N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences – Nadezhda Ustyuzhanina Nikolay Nifantiev
Link to the full article on ScienceDirect
DOI: https://doi.org/10.1016/j.carres.2022.108701Get rights and content
A new automated glycan synthesizer offering one-pot chemical glycosylations in the solution presented by Sir Fraser’s team from Northwestern University: Yong Wu, Yunyan Qiu, and Yuanning Feng
https://pubs.acs.org/doi/10.1021/acscentsci.2c01043
