Now, this is something we have never seen before. Delivering oligonucleotides into cells using cyclodextrin-based nanoparticles has been studied a lot, yet in the paper from Chongqing University, intranucleus delivery of proteins is shown. This will certainly open up new drug delivery possibilities for the future and trigger novel applications.
Read the full article on ScienceDirect
Amazing therapeutic success led by UCSF Pediatrics joined by Duke University, Ottawa University, and Washington University via in-utero enzyme-replacement therapy for infantile-onset Pompe’s disease: Patients with early-onset lysosomal storage diseases are ideal candidates for prenatal therapy because organ damage starts in utero. After receiving in-utero ERT and standard postnatal therapy, the current patient had normal cardiac and age-appropriate motor function postnatally, was meeting developmental milestones, had normal biomarker levels, and was feeding and growing well at 13 months of age.
Cyclo Therapeutics, Inc. sponsors Phase II trial for early Alzheimer’s disease. The study will enroll approximately 90 male and female patients aged 50 to 80 years who will be given a minimum active dose of 500 mg/kg of Trappsol Cyclo (equivalent to 18,500 mg/m2) as an intravenous (IV) infusion once every 28 days for 6 months.
We wish the best of success to our colleagues at Cyclo Therapeutics and hope this therapy will prove useful for the benefit of these patients.
Having programs ourselves in developing NCEs for neurodegenerative diseases, we find this study particularly essential.
Read more about the clinical trial here
Have you ever tried using cyclodextrin to prevent protein folding and to stabilize them with such safe excipients instead surface active agents? From the patent of Tamas Sohajda, our board member, you can learn more about this potential.
Cyclodextrin in diagnostics? Why not? Chaudhary Charan Singh University (NAZIA TARANNUM, Deepak Kumar, Yeshvandra Verma) presents Selectively Imprinted β-cyclodextrin Polymer for Colorimetric Assay of Lysophosphatidic Acid for Point of Care Detection of Ovarian Cancer
Using sugars in a prodrug concept is a fascinating idea as these compounds can bring so much to the table like improve stability, PK, or help in targeting. In this patent from Heidelberg University oligosaccharide conjugated prostate-specific membrane antigens are described where the bonds are cleaved by amylase in the body.
Oral, topical, and agrochemical uses of nanochitin presented by Shinsuke Ifuku from Tottori University.
We truly believe in the potential cyclodextrin hold in drug delivery in traditional formulations and upcoming applications like protein and oligonucleotide delivery, controlled or targeted release, and nanotechnology. Of course, our research is closer to the latter applications.
In this review published by Universidade de Coimbra (Laura Ferreira, Joana Campos, Francisco Veiga Catarina Cardoso, and Ana Cláudia Paiva-Santos), parenteral applications and their potential a summarized very well.
Great educative read!
From peptides to sugars: Design, Synthesis, and Characterization of Stapled Oligosaccharides. Oligosaccharide stapling increases enzymatic stability and cell penetration, opening new opportunities for using glycans in medicinal chemistry. – Max Planck Institute Manuel Garcia Ricardo, Emelie Ellen Reuber, Ling Yao, José Angel Danglad-Flores, Martina Delbianco, Peter Seeberger
Wonderful chemistry and insightful new possibilities.
Peter Seeberger, Felix Loeffler et al. from Max Planck Institute of Colloids and Interfaces published a #chemical vapor glycosylation strategy (VaporSPOT) that enables the simultaneous #synthesis of oligosaccharides on a cellulose #membrane.
Amazing study!
Full article: https://pubs.acs.org/doi/10.1021/jacs.2c07285
