Cyclodextrin as a green anti-agglomerate agent in oil-water emulsion containing asphalt

Today's cyclodextrin, , ,

University of Science and Technology Beijing presents a very unique use of CDs:
Anti-agglomerate agents (AAs) are a cost-effective method to prevent hydrates from clogging submarine oil/gas pipelines. However, conventional AAs such as Span 80 is not applicable in oil/gas pipelines rich in asphalt because asphalt is easy to occupy the binding sites on the water droplet surface. On the other hand, CDs show excellent anti-agglomerate characteristics in oil–water systems containing asphalt by forming stable hydrogen bonds with water molecules. Compared with Span 80, the initial contact time between water droplets and hydrate is delayed by five times after adding CD molecules. CD-asphalt interaction prevents water droplets from spreading on the hydrate surface by maintaining the stability of the emulsion.
The unique properties of CD provide a molecular basis for developing more green and efficient AAs.

See the full article here.


Methyl-BCD is used in antibody-drug conjugate

Today's cyclodextrin, ,

An interesting application is highlighted in the patent of RemeGen荣昌生物: methyl-BCD is used in antibody-drug conjugate formulations where the primary benefit is that ADC dose can be lowered (due to higher efficacy), which leads to mitigating safety concerns lowering costs, and patient treatment costs. Fascinating, huh? (Figure: Araris Biotech AG)

See the full patent on Espacenet.


Method for stabilizing the pH of an aqueous composition comprising a drug

Today's cyclodextrin,

While the mainstream use of CDs in pharma is solubilization, improving chemical stability is close to 2nd most popular, even though it is more complicated to achieve. This patent by Thorsteinn Loftsson (Oculis S.A.) and Zoltán Fülöp encorporates a nice case study of preventing the oxidation of corticosteroids.

See the full patent on PatentScope


Improvement of Fertilization Capacity and Developmental Ability of Vitrified Bovine Oocytes by JUNO mRNA Microinjection and Cholesterol-Loaded Methyl-β-Cyclodextrin Treatment

Today's cyclodextrin,

This is a little reminder of the great potential to use these compounds (especially # cholesterol-loaded methyl-beta-cyclodextrin) to improve fertilization capacity. The fertilization and development ability of vitrified bovine oocytes were improved by the combination treatment of JUNO mRNA microinjection and CLC/MβCD – Chinese Academy of Agricultural Sciences

Read the full article here

Controlled drug delivery mediated by cyclodextrin-based supramolecular self-assembled carriers: From design to clinical performances

Today's cyclodextrin, ,

A great compilation on the controlled drug delivery mediated by cyclodextrin-based supramolecular self-assembled carriers: From design to clinical performances at Pharma Excipients International AG compiled by University POLITEHNICA of Bucharest (Jana Ghitman and Voicu Stefan Ioan)

See the full article here

Green β-cyclodextrin-based corrosion inhibitors: Recent developments, innovations and future opportunities

Today's cyclodextrin,

A great review on a unique industrial application: Green β-cyclodextrin-based corrosion inhibitors from National University of Uzbekistan, University of South Africa/Universiteit van Suid-Afrika, Ibn Tofail University, Yeungnam University and Sidi Mohamed Ben Abdellah University

See the full article here

Great learning opportunity presented by Ajay Semalty on CD complexes in general

Today's cyclodextrin,

Great learning opportunity presented by Ajay Semalty on CD complexes in general. Here you can learn about CD chemistry and basic properties and techniques to make complexes, and analyze them shown in several practical examples. Extremely informative!
Please share and spread the word.

Cyclodextrin Complexes I
Cyclodextrin Complexes II