How often are you doing chores? Here is a tip by Henkel AG & Co. KGaA: use CDs (treat textile) when you do the laundry to reduce malodor in the area.
Marc Weyhe, Lea Berg
See the full patent on Patentscope
According to this patent from Eastpond Labs, a CD-containing beverage could improve the cellular hydration efficiency of our drinks. Moreover, the beverage composition could increase the lifespan in the multicellular organism.
Rather ambitious and very exciting. I cannot wait to see some data on more complex beings than C elegans.
What is your opinion? Could this actually work on humans?
See the full patent on Espacenet
Using CDs to stabilize drugs chemically is rather frequently used. But did you know that they can also be used to stabilize radiopharmaceuticals? According to the patent of GE HealthCare (Kristine Opsvik Wikene; Kahn Imtiaz Ahmed; Graeme McRobbie) combined with a radiostabilizer (like ascorbic acid), a cyclodextrin as co-stabilizer improves the stability of radiopharmaceuticals compared to using a conventional stabilizer.
See the full patent on Espacenet.
Have you ever wondered how cyclodextrins fit into modern, fancy formulation technologies like 3D printing? Nunzio Denora and his group at Università degli Studi di Bari and Institute of Crystallography – CNR show how to make budesonide-loaded mini-tablets using direct cyclodextrin-based powder extrusion 3D printing.
Monica Pistone, Giuseppe Francesco Racaniello, rosanna rizzi, Rosa Maria Iacobazzi, Ilaria Arduino, Antonio Lopalco, Angela Assunta Lopedota
University of Science and Technology Beijing presents a very unique use of CDs:
Anti-agglomerate agents (AAs) are a cost-effective method to prevent hydrates from clogging submarine oil/gas pipelines. However, conventional AAs such as Span 80 is not applicable in oil/gas pipelines rich in asphalt because asphalt is easy to occupy the binding sites on the water droplet surface. On the other hand, CDs show excellent anti-agglomerate characteristics in oil–water systems containing asphalt by forming stable hydrogen bonds with water molecules. Compared with Span 80, the initial contact time between water droplets and hydrate is delayed by five times after adding CD molecules. CD-asphalt interaction prevents water droplets from spreading on the hydrate surface by maintaining the stability of the emulsion.
The unique properties of CD provide a molecular basis for developing more green and efficient AAs.
An interesting application is highlighted in the patent of RemeGen荣昌生物: methyl-BCD is used in antibody-drug conjugate formulations where the primary benefit is that ADC dose can be lowered (due to higher efficacy), which leads to mitigating safety concerns lowering costs, and patient treatment costs. Fascinating, huh? (Figure: Araris Biotech AG)
See the full patent on Espacenet.
A fascinating patent application by Hologic, Inc. using CDs in enzyme formulations for nucleic acid amplification. The compositions are also useful in mitigating the inhibitory effect of sample extraction detergents.
See the full patent on PatentScope
While the mainstream use of CDs in pharma is solubilization, improving chemical stability is close to 2nd most popular, even though it is more complicated to achieve. This patent by Thorsteinn Loftsson (Oculis S.A.) and Zoltán Fülöp encorporates a nice case study of preventing the oxidation of corticosteroids.
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This is a little reminder of the great potential to use these compounds (especially # cholesterol-loaded methyl-beta-cyclodextrin) to improve fertilization capacity. The fertilization and development ability of vitrified bovine oocytes were improved by the combination treatment of JUNO mRNA microinjection and CLC/MβCD – Chinese Academy of Agricultural Sciences
A great compilation on the controlled drug delivery mediated by cyclodextrin-based supramolecular self-assembled carriers: From design to clinical performances at Pharma Excipients International AG compiled by University POLITEHNICA of Bucharest (Jana Ghitman and Voicu Stefan Ioan)
