Covalent linkages are engineered between proteins and carbohydrates under biocompatible conditions. Genetically encoding the chemical crosslinking of proteins to carbohydrates offers a solution to address the low affinity and weak strength of protein–sugar interactions.
The University of California, San Francisco – Shanshan Li, Nanxi Wang, Bingchen Yu Wei Sun Lei Wang present pure beauty!
Read the full article on nature.com
Jellyfish is considered a new potential resource in the food, pharmaceutical, and biomedical industries. In this study presented by Università di Pisa (Chiara Migone Noemi Scacciati Brunella Grassiri Alessandra Braca Dario Puppi Anna Maria Piras et al), skin polysaccharides with glycosaminoglycan features were extracted, and their use as promoters of wound-healing was evaluated
Tetsumi Irie form Kumamoto University explains the differences in the mechanisms of action for HPBCD and HPGCD in the treatment of Niemann-Pick C.
Full article: https://doi.org/10.1248/yakushi.21-00215
Hyaluronic acid-related oligosaccharides were evaluated as potential antiangiogenic agents by N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences – Nadezhda Ustyuzhanina Nikolay Nifantiev
Link to the full article on ScienceDirect
DOI: https://doi.org/10.1016/j.carres.2022.108701Get rights and content
A new automated glycan synthesizer offering one-pot chemical glycosylations in the solution presented by Sir Fraser’s team from Northwestern University: Yong Wu, Yunyan Qiu, and Yuanning Feng
https://pubs.acs.org/doi/10.1021/acscentsci.2c01043
The cyclodextrin-supported atherosclerosis treatment field is getting crowded. Here is a unique approach using polyethylene glycol succinate (TPGS)-CD, which was adsorbed on rHDL, then modified with Apo-Ai, and coated with hyaluronan to obtain HT-rHDL. Piece of cake!
China Pharmaceutical University
Full article on ScienceDirect
https://doi.org/10.1016/j.carbpol.2022.119632
We are excited to present the following member of the CarboHyde family, joining the experts of the Scientific Advisory Board. Szabolcs Béni is a widely known expert in carbohydrate analysis and extraction from different plants whose knowledge will be one of our core assets in the progression of our pipeline.
Szabolcs is the vice-dean and department head of the Faculty of Pharmacy, Department of Pharmacognosy at Semmelweis University, who enjoys working with students while engaged in chemical research of various carbohydrates. Analytical method developments for the characterization of cyclodextrins, milk oligosaccharides, and glycosaminoglycans are in the focus of his interest. NMR spectroscopy, Mass Spectrometry, and various separation techniques are in his toolbox to tackle the issues raised by chemists and biologists for carbohydrate characterization to advance understanding of their functions.
We are happy to announce that Gergely Tóth will join the team of CarboHyde as a Strategic Director, responsible for the company’s financial, legal, and other functional areas.
Gergely has 2+ years of experience in the pharma sector; prior to that, he had worked in various roles in the energy industry.
“I Think This Is The Beginning Of A Beautiful Friendship!
I’m very excited to join a great Pharmaceutical startup, CarboHyde, as a Director of Strategy. I will be responsible for the financial, legal, and other functional areas. Here, we develop carbohydrate-based therapies and will help others to do so. Moreover, we are committed to building a TEAL-based company culture, which we believe will be a key strength of our company.”
Welcome on board, Gergely!
We are proud to share the next member in the CarboHyde family, joining our excellent experts on the Advisory Board. Ákos Lőrincz has a complementary experience in physiology and immunology; we all respect and need to advance our pipeline most efficiently.
Ákos is an Assistant Professor at Semmelweis University, Institute of Physiology, and a practicing cardiologist. His scientific interest is the biology of extracellular vesicles, particularly the formation of immune cell-derived extracellular vesicles and their role in immune communication. He is also convinced that the general goal of basic research is to acquire knowledge that can be applied in clinical work; therefore, he is intensively studying these vesicles’ diagnostic and therapeutic potential.
Related to carbohydrates, the surface of cellular and subcellular biological structures (e.g., extracellular vesicles) is covered with carbohydrates. The role of the glycocalyx in the formation and addressing of vesicles has already been demonstrated. In his research, He is looking for the answer to whether media with different carbohydrate compositions can increase the stability of storage-sensitive vesicle structures.
Welcome on board, Ákos!
The CarboHyde team is planning for its first conference attendance at the upcoming International Cyclodextrin Symposium (13-17th June, Sicily), where our team will deliver presentations on cyclodextrin-based therapeutic potential.