Fascinating cyclodextrin conjugation chemistry from Southwest Jiaotong University in order to target the hydroxyapatite component of the bone. We are also highly involved in conjugating peptides and carbohydrates to create actives and drug delivery systems. Have you ever considered a peptide-CD conjugate for such an application?
Science masterpiece by Università degli Studi di Milano-Bicocca – Laura Russo, who presents the development of a 3D printed colorectal cancer model discovering that hyaluronic acid and gelatin glycosylation influences the construct morphology, and protein profiles of tumoroid cells
Mindblowing study!
See the full article here
A fascinating novel concept of cancer research using lectibodies, a bispecific construct composed of a lectin linked to an antibody fragment. This approach aims to redirect the immune system into fighting cancer by targeting altered glycans at the surface of malignant cells.
The University of Freiburg, acib GmbH – Francesca Rosato, Rajeev P., Jana Tomisch, Ana Valeria Meléndez Mayorga, Dajana Kolanovic, Olga Makshakova, Birgit Wiltschi, Winfried Römer
Easy to digest review on drug delivery of CD-based nanoparticles for the delivery of tyrosine kinase inhibitors and the synthesis methods of cyclodextrin-based compounds.
Greennanotech kft, Nanoscitec_gmbh, NanoSciTech GmbH
Do you also have the sensation that the achievements and success of others inspire you to do more and better? If so, this collection of GlycoNet goes well with your Friday coffee:
10 success stories from 2022 in glycomics:
1. Alectos Therapeutics Inc. – Ernest McEachern
2. Université de Montréal – Mariela Segura
3. GlyCa Biosciences, Huron Innovation – Hon Leong, John Klassen, Karla Williams, and John Trant.
4. Carolyn Bertozzi, Morten Meldal, Barry Sharples – no comment needed
5. Karimah Es Sabar and GlycoNet
6. INRS-Institut Armand-Frappier – Yves St-Pierre
7. Université Laval – Masahiko Sato, Ann Rancourt, Sachiko Sato, Julie-Christine Lévesque, Guillaume St-Pierre, and Maude F.
8-10. University of Alberta – Christopher Cairo, Matthew Macauley, Simonetta Sipione
See detailed information on the GlycoNet website
New kid on the block: Asterivir’s website has just gone live. Asterivir – a spinout from EPFL (École Polytechnique fédérale de Lausanne) – develops CD-based broad spectrum antivirals lead by Francesco Stellacci, Paulo Jacob Silva and Oscar Buset. The initial findings of the company were published earlier (Caroline Tapparel Vu et al. )
The website contains nice video graphics of the mechanism of action, which is worth checking!
This research contributes to a better understanding of the mechanism of action of #cyclodextrin in Niemann Pick C, which could lead to further applications. Carmen Vargas – Federal University of Rio Grande do Sul evaluated naked and nanoparticle CDs for restoring mitochondrial functions, as well as the beneficial combined effects of treatment with antioxidant N-Acetylcysteine and Coenzyme Q10
Tatiane Hammerschmidt, Bruna Donida, Jéssica Lamberty Faverzani, Fernanda Poletto, Dinara Jaqueline Moura
Fresh from the oven of the Francesco Trotta and Adrián Matencio Durán (Università degli Studi di Torino) lab, two papers on the uses of hyper-branched CD-polymer:
No 1: use as an anticoagulant, which is a very innovative application for CDs that are getting more and more spotlight
No 2: use as transfection promoters of plasmids.
I congratulate you on this ambitious research goal, loved both papers and look forward to seeing from sprouting from the collaboration you recently started with CarboHyde!
Yousef Khazaei monfared, Mohammad Mahmoudian, Claudio Cecone, Fabrizio Caldera, Sanya Haiaty, Reza Rahbarghazi, Parvin Zakeri-Milani, Gjylije Hoti, Fabrizio Caldera, Roberta Cavalli
Understanding the mechanism of action is crucial in order to develop truly efficient cyclodextrin-based actives. Massachusetts Institute of Technology’s study on Alzheimer’s disease reveals correlations between APOE4, cholesterol transport, and therapeutic opportunities for CDs.
Important study Joel Blanchard, Li-Huei Tsai et al.
See the full article on nature.com
Great overview of CD-based drug delivery systems for cancer therapy from Carol Davila University of Medicine and Pharmacy and University POLITEHNICA of Bucharest
Monica Alexandra Bolocan, Octavian Andronic, Alexandru Mihai Grumezescu, Rodica Birla
