Dani Bisericaru goes to Buenos Aires to learn from Carlos Modenutti and try to model how our cyclodextrins interact with some proteins we target.
Super excited about the outcome, enjoy your secondment, Dani!
Today’s discussion is about water purification using cyclodextrin, but from a different perspective.
Last week, the largest pharmaceutical exhibition of the year took place in Milan. CPHI, recognized as the world’s premier pharmaceutical event, hosts six distinct exhibitions covering the entire pharmaceutical sector—from ingredients and finished dosage forms (FDF) to machinery, packaging, outsourcing, and biopharmaceuticals.
Over 2,300 exhibitors presented their products and services to approximately 60,000 attendees, representing every part of the pharmaceutical supply chain, all within three days. CPHI provides a unique opportunity for professionals to connect, explore innovations, and stay up-to-date with the latest developments in the industry.
Tamás Sohajda, Gergely Tóth, and Tamas Vargadi represented CarboHyde. Throughout the event, they participated in around 80 meetings with partners, exhibitors, and new connections. Despite the pharmaceutical industry’s ever-changing landscape, CPHI remains one of the best venues for networking, bringing together professionals from across the sector in one place.
The event provided an opportunity to engage with Sugammadex manufacturers, cyclodextrin producers and formulators, contract manufacturing organizations (CMOs), formulation experts, as well as professionals from R&D, procurement, business development, and more.
CPHI offered those interested in cyclodextrins the chance to connect with many key players. Attendees could meet Sugammadex API manufacturers, integrated pharma companies using cyclodextrins in their formulations, and major manufacturers such as WACKER, Roquette, Cyclolab R&D Ltd. or Zibo Qianhui Biological Technology Co.,Ltd. Distributors such as Ashland and Barentz were also present, showcasing their products and services.
I highly recommend CPHI to anyone who has yet to experience it. The 2025 edition promises to be another invaluable event filled with opportunities to learn, connect, and grow within the industry.
In the coming weeks, CarboHyde will continue to focus on using cyclodextrins as active ingredients, with content covering their application in treating various diseases.
Enhancing Oral Drug Absorption
is the ultimate goal of using cyclodextrins. This great paper shows how Physiological and Pharmaceutical Barriers can be overcome for Improved Bioavailability.
Rashmi Maurya, Akash Vikal, Dr. Preeti Patel, Raj Kumar, & Dr. Balak Das Kurmi
Do you enjoy wine? Enjoy it better with cyclodextrin!
The weekend is almost here, so it’s time to enjoy some wine – with CDs, of course!
From this paper, you can learn about the protective effect of the post-fermentation addition of CDs on the color stability of red wine from the viewpoints of color characteristics, pigmentation, and phenolic profiles.
The evolution of anthocyanin form and the content of monomeric anthocyanins revealed that β-CD is a superior favorable cofactor during wine aging. Still, for long-term aging, 2-HP-β-CD and 2-HP-γ-CD are more beneficial in promoting the formation of polymerized anthocyanins and color stability.
Not many things get better with years passing but some do.
Things like:
– whiskey,
– wine
– blue jeans
– friendships
and Thorsteinn Loftsson
This was my first thought when reading this paper, which I coauthored with Hay Man Saung Hnin Soe and Phatsawee Jansook on cyclodextrin-based nanoparticles.
This review emphasizes the role of cyclodextrins (CDs) in stabilizing colloidal nanoparticles (NPs) and improving drug solubility. The integration of CDs with NPs offers a synergistic strategy that enhances drug delivery and expands the scope of biomedical applications. Furthermore, the review thoroughly explores the potential of CDs to boost the stability and therapeutic effectiveness of colloidal NPs, positioning them as promising candidates for advanced drug delivery systems
ONE way to boost your performance!
Today’s cyclodextrin is another clinical study showing the benefits of using alpha-cyclodextrin to improve exercise performance and reduces post-exercise fatigue.
α-Cyclodextrin (αCD), a cyclic hexasaccharide composed of six glucose units, is not digested in the small intestine but is completely fermented by gut microbes.
αCD supplementation significantly improved endurance exercise performance (10 km biking time trial) compared with the placebo.
The heart rate increase was lower in the αCD group than in the placebo group during exercise.
On Day 1, we started with with students sharing results and plans from their secondments, then moved along to hear from PIs about challenges, possibilities and wishes regarding the project.
Day 2 was dedicated to science with our invited speakers Matthieu Sollogoub, Francesco Trotta and Dina Yannakopoulou followed by lectures from Jose Manuel Garcia Fernandez and Milo Malanga PhD (dreaming about making synthesis simple and sustainable) and we created some hypothetic ventures with Gergely Toth.
Day 3-4 was a mix of science and soft skills with analytical lectures (Ilse Manet and Szabolcs Béni) and cyclodextrins in electrosensors (Maria Antonietta Casulli). The last sessions of the workshop dealt with soft skills rather than science. Tamas Sohajda shared insights of using social media and AI for making science more accessible. Then Ilse Manet, Maria Antonietta Casulli and Barbara Ventura delivered a workshop about grantwriting.
And most importantly, behold the organizing committee from Eötvös Loránd University and CarboHyde:
Today’s cyclodextrin is an easy review on Advances in Cyclodextrins and Their Derivatives in Nano-Delivery Systems
The areas covered include nanospheres, nano-sponges, nanogels, cyclodextrin metal–organic frameworks, liposomes, and emulsions, providing a comprehensive and in-depth understanding of the design and development of nano-delivery systems.
Advances in Cyclodextrins and Their Derivatives in Nano-Delivery Systems (mdpi.com)
Today’s cyclodextrin:
I have seen many visualizations and artwork of cyclodextrins so far, yet this “jellyfish” cover caught my eye.
Cholesteryl-modified cyclodextrin (also a great idea) to capture and deliver 5-fluorouracil.
