Cyclodextrins: Establishing building blocks for AI-driven drug design by determining affinity constants in silico

Today's cyclodextrin,

Today’s cyclodextrin:
Check out this fascinating paper guiding us to the future of CDs:

AI-driven cyclodextrin drug design

Fascinating research by Amelia Anderson & Matthew “Oki” O’Connor from Cyclarity Therapeutics and Angel Piñeiro & Rebeca Garcia-Fandino from Universidad de Santiago de Compostela

Computational methods represent an exceptional complement to in vitro assays because they can be employed for existing and hypothetical molecules, providing high resolution structures in addition to a mechanistic, dynamic, kinetic, and thermodynamic characterization.

Bridging computational methods with complex molecular interactions, this research enables predictive CD designs for diverse applications. Moreover, the high reproducibility, sensitivity, and cost-effectiveness of the studied methods pave the way for extensive studies of massive CD-ligand combinations, enabling AI algorithm training and automated molecular design.

Cyclodextrins: Establishing building blocks for AI-driven drug design by determining affinity constants in silico – Computational and Structural Biotechnology Journal (csbj.org)

CPHI 2024: The Premier Event for the Pharmaceutical Industry is Just Around the Corner

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The most anticipated pharmaceutical event of the year is fast approaching! CPHI 2024, set to take place in Milan from October 8-10, is the world’s largest pharmaceutical exhibition. This event is a unique convergence of six individual pharma sectors, covering every aspect of the industry—from ingredients and FDF to machinery, packaging, outsourcing, and biopharmaceuticals.

What to Expect at CPHI 2024

This year’s CPHI is shaping up to be bigger and better than ever. Here’s what attendees can look forward to:

  • 62,000 attendees from across the globe
  • 2,400 exhibitors showcasing the latest innovations and services
  • 166 countries represented, making it a truly global gathering
  • 150+ expert speakers sharing insights and trends shaping the future of pharma

For those who have previously attended a CPHI event, you’ll know that it’s tailored specifically for professionals in the pharmaceutical industry. Whether you’re looking to network, learn, or explore new business opportunities, CPHI is the place to be.

Spotlight on Cyclodextrins

Among the myriad of products and technologies on display, cyclodextrins will feature prominently at CPHI 2024. Expect to meet a wide range of users and manufacturers of cyclodextrins, including:

And, of course, CarboHyde will be there too. Our team will be well-represented, with CFO Gergely Toth, COO Tamás Vargadi, and Tamas Sohajda all attending the event. We’re excited about the opportunity to engage with industry peers and discuss potential collaboration on cyclodextrin projects.

Let’s Connect at CPHI 2024

If you’re planning to attend CPHI in Milan, we would love to catch up with you. This event presents a fantastic opportunity to plan and strategize around cyclodextrin-related projects. We believe that face-to-face interactions at such a prestigious event can pave the way for meaningful collaborations.

We look forward to seeing you there!

Preparation of Carvacrol β-Cyclodextrin Inclusions and 1-Methylcyclopropene-α-CD Coated Paper by Water-Free Method for Postharvest Preservation of Peach

Today's cyclodextrin

Today’s cyclodextrin: is a packaging/food preservation application

Where Carvacrol β-Cyclodextrin Inclusions and 1-Methylcyclopropene-α-CD Coated Paper are for post-harvest preservation of peach.

Carvacrol essential oil has broad-spectrum antibacterial properties, but it is volatile and unstable for long-term storage and use. In the present study, carvacrol was encapsulated with β-cyclodextrin to improve its relevant properties.

PEG was used to form the film in the anhydrous condition, and the compound and ethylene inhibitor 1-methylcyclopropene (1-MCP) were included to obtain the film-coated paper.

This study provides a solution for preparing controlled-release coated paper with essential oils and 1-MCP bioactives to extend the shelf life of fruits and vegetables.

Preparation of Carvacrol β-Cyclodextrin Inclusions and 1-Methylcyclopropene-α-CD Coated Paper by Water-Free Method for Postharvest Preservation of Peach | Food and Bioprocess Technology (springer.com)

β-Cyclodextrin nano-encapsulated carvacrol inclusion complexes improve postharvest quality of limes (Citrus latifolia Tanaka) (usda.gov)