Cyclodextrin-loaded nanobubbles reduce cholesterol and atherosclerosis in vivo

drug delivery, ,

While the uses of cyclodextrin as active ingredients is emerging both by the number of target diseases, companies developing them and types of CDs used, their efficient delivery remains a challenge.
The nanobubbles presented here could incorporate the CDs, accumulate in the atherosclerotic lesions, the release of CD and the reduce the total plaque area in the entire aorta and eventually reduce cholesterol level in mice plasma.
Cyclodextrin-loaded nanobubbles reduce cholesterol and atherosclerosis in vivo | European Heart Journal | Oxford Academic (oup.com)

Therapeutic polypseudorotaxane hydrogels

carbohydrates, drug development

Qrons Inc. – ido merfeld propose using polyrotaxanes (which are “necklace” like molecules where the “pearls” are cyclodextrins and in this invention the “chain” is a polymer of ethylene oxide) for manufacturing a medicament for Central Nervous System. The proposed examples include piping into the brain for treatment of traumatic brain injury.
If you are interested in creating such innovative constructs from cyclodextrins, check out this site for possibilities, we can probably help: Custom synthesis of cyclodextrins – www.carbohydesolutions.com

WO2023194821 THERAPEUTIC POLYPSEUDOROTAXANE HYDROGELS (wipo.int)

Cyclodextrin incorporated silicone materials and their use as carriers for actives

drug delivery, Today's cyclodextrin,

today’s cyclodextrin is an innovation from WACKER (Amitabha Mitra, Megan Gutman, Christian Hartman and Vera Popova) where cyclodextrins are part of a silicone composition creating articles for absorption, encapsulation and delivery of actives and other compounds. Example of such articles could be transdermal patches, PSAs, medical device, membranes, gels, clothing or other wearable materials, etc. The invention can be used for various applications including cosmetics, medical, home care, textiles, industrial and others.

WO2023208316 CYCLODEXTRIN INCORPORATED SILICONE MATERIALS AND THEIR USE AS CARRIERS FOR ACTIVES (wipo.int)

Live Q&A on Cyclodextrins

Egyéb kategória, news,

Breaking News: Live LinkedIn Q&A Session on Cyclodextrins Unveils Insights from Industry Experts!

Join us for an exclusive live event on LinkedIn as we delve into the fascinating world of cyclodextrins! This dynamic Q&A session brings together industry experts, researchers, and enthusiasts to explore the diverse applications and cutting-edge advancements in the field of cyclodextrin science.

📅 Date & Time: January 23, 2024 14.00 CET

📍 Location: LinkedIn Live – https://www.linkedin.com/events/7150478953097469953/?lipi=urn%3Ali%3Apage%3Ad_flagship3_company_admin%3BUXLAZXmBRdGB89QgeEFQdA%3D%3D

What to Expect:

  1. Insider Insights: Gain a deeper understanding of cyclodextrins and their versatile applications across various industries, from pharmaceuticals to food and beyond.
  2. Expert Panel: Engage with a panel of distinguished experts who will share their knowledge, experiences, and perspectives on the latest developments in cyclodextrin research.
  3. Interactive Q&A: Pose your burning questions directly to the experts during the live session. Get real-time answers and insights that matter to you.
  4. Networking Opportunities: Connect with like-minded professionals, researchers, and industry leaders who share a passion for cyclodextrin science.

How to Participate:

  • Follow our LinkedIn page to receive notifications and updates about the live event.
  • Set a reminder for the scheduled date and time to ensure you don’t miss out on this unique opportunity.
  • Prepare your questions in advance to make the most of the interactive Q&A session.

Who Should Attend:

  • Researchers and scientists in the fields of chemistry, pharmaceuticals, and materials science.
  • Professionals in industries utilizing cyclodextrins, including pharmaceuticals, food and beverages, cosmetics, and more.
  • Students and academics interested in gaining insights into the latest advancements in cyclodextrin research.

Don’t miss this chance to be part of a vibrant community discussing the groundbreaking advancements in cyclodextrin science! Mark your calendars and join us for an engaging and informative live Q&A session.

Stay tuned for more updates and surprises during the event! 🚀

If you follow us, you know that we are keen to spread the word about cyclodextrins and create educational content. Now, we would like to get closer to you and answer any questions you may have directly. Formulation, analysis, chemistry, business, future applications, everything is on the table.

Feel free to join and ask directly from our CEO, Tamas Sohajda.

You can register and learn more here: 

📍 Location: LinkedIn Live – https://www.linkedin.com/events/7150478953097469953/?lipi=urn%3Ali%3Apage%3Ad_flagship3_company_admin%3BUXLAZXmBRdGB89QgeEFQdA%3D%3D

Thermal response liquid intelligent window and preparation method

Today's cyclodextrin, ,

today’s cyclodextrin is something smart and unique – heat-responsive, intelligent window. In practice, temperature-sensitive cyclodextrin as a solute and water and glycerol as solvents are injected into an interlayer of a double-layer window panel to obtain the thermal response liquid intelligent window. The thermal response liquid intelligent window is prepared from safe, non-toxic and environment-friendly raw materials through a simple and feasible preparation method in accordance with the green and environment-friendly concept. The window is remarkable in anti-freezing capability, is high in transparency in a cold state, is high in response speed after being heated, is quickly turned into an opaque state, and can effectively modulate the sunlight transmittance.

Please read the full patent here: Espacenet – search results

Folate-Appended Hydroxypropyl-β-Cyclodextrin Induces Autophagic Cell Death in Acute Myeloid Leukemia Cells

drug development, , ,

More and more uses of cyclodextrin as anticancer therapy agents come to light these days. The most recent is the research of Kumamoto University (who else) showing how Folate-Appended Hydroxypropyl-β-Cyclodextrin (FA-HP-β-CyD) Induces Autophagic Cell Death in Acute Myeloid Leukemia (AML) Cells.

As reported the cytotoxic activity of FA-HP-β-CyD against AML cells was stronger than that of HP-β-CyD. Also, FA-HP-CyD induced the formation of autophagosomes in AML cell lines. FA-HP-β-CyD increased the inhibitory effects of cytarabine and a BCL-2-selective inhibitor, Venetoclax, which are commonly used treat elderly AML patients. Notably, FA-HP-β-CyD suppressed the proliferation of AML cells in BALB/c nude recombinase-activating gene-2 (Rag-2)/Janus kinase 3 (Jak3) double-deficient mice with AML. These results suggest that FA-HP-β-CyD acts as a potent anticancer agent for AML chemotherapy by regulating.

IJMS | Free Full-Text | Folate-Appended Hydroxypropyl-β-Cyclodextrin Induces Autophagic Cell Death in Acute Myeloid Leukemia Cells (mdpi.com)

Figure 2
FA-HP-β-CyD induces apoptosis in HL-60, THP1, SKM1, and Kasumi1 cells. (A) HL-60, THP1, SKM1, and Kasumi1 cells were treated with 0 (medium only), 0.5, 1.0, and 1.5 mM of FA-HP-β-CyD for 72 h. After 72 h, cells were stained with Annexin V and PI. Representative FCM plots are shown (n = 3). (B–E) Percentage of Annexin V-positive PI-negative cells after exposure to FA-HP-β-CyD for 72 h. (B) HL-60, (C) THP1, (D) Kasumi1, (E) SKM1 cells. Data represent the mean ± SEM of three independent experiments. * p < 0.05.