Glycan hairpin created by combining natural glycan motifs, stabilized by a non-conventional hydrogen bond and hydrophobic interactions.
Fantastic work by Peter Seeberger, Jesus Jimenez-Barbero, Martina Delbianco et al.
You can find the complete article by clicking on the link provided.
A review in Science Magazine by Greg Sepich-Poore, Ph.D. et al. looked at research that shows how bacteria, viruses and fungi of the microbiome are pervasive among human cancers, are key actors in cancer immunotherapy, and are potentially engineerable to treat metastases. Advances in microbiome research are improving our understanding of immuno-oncology and driving new diagnostic and therapeutic approaches.
Check out the article at the following link.
Today’s cyclodextrin:
some CD-supported plant coffee to reduce off-flavor. There is indeed no limit to the use of CDs.
You may find the patent on Espacenet.
Core member of our advisory board, Szabolcs Béni from Semmelweis University, giving a talk about cyclodextrin and Sugammadex analysis at the 33rd International Symposium on Pharmaceutical and Biomedical Analysis, organized by Ankara University – Sibel A. OZKAN
Fantastic cyclodextrin chemistry by Carmen Ortiz Mellet, Jose Manuel Garcia Fernandez, and Francisco Mendicuti et al.
β-cyclodextrin (βCyD) derivatives equipped with aromatic appendages at the secondary face exhibit tailorable self-assembling capabilities. Supramolecular species can thus form that, at their turn, can engage in further co-assembling with third components in a highly regulated manner; the design of nonviral gene delivery systems is an illustrative example.
Today’s cyclodextrin:
γ-cyclodextrin (γCD)-based nanoparticles (NPs) for dual antitumor therapy
γCD was chemically conjugated with low-molecular-weight hyaluronic acid (HA; a tumoral CD44 receptor-targeting molecule) and 3-(diethylamino)propylamine (DEAP; a pH-responsive molecule), yielding γCD-(DEAP/HA) which self-assemble in water to for NPs. These NPs efficiently entrapped paclitaxel (PTX) and triiron dodecacarbonyl (FeCO). These NPs were efficiently internalized by MCF-7 tumor cells expressing CD44 receptors and enhanced PTX/FeCO-mediated tumor cell apoptosis. Importantly, local light irradiation of FeCO stimulated the generation of cytotoxic CO, resulting in highly improved tumor cell death.
